The importance of a single primary cilium
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چکیده
منابع مشابه
The importance of a single primary cilium
The centrosome is the main microtubule-organizing center in animal cells, and helps to influence the morphology of the microtubule cytoskeleton in interphase and mitosis. The centrosome also templates the assembly of the primary cilium, and together they serve as a nexus of cell signaling that provide cells with diverse organization, motility, and sensory functions. The majority of cells in the...
متن کاملSignaling through the Primary Cilium
The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in...
متن کاملThe primary cilium at a glance.
This article is part of a Minifocus on cilia and flagella. For further reading, please see related articles: ‘Sensory reception is an attribute of both primary cilia and motile cilia’ by Robert A. Bloodgood (J. Cell Sci. 123, 505-509), ‘The perennial organelle: assembly and disassembly of the primary cilium’ by E. Scott Seeley and Maxence V. Nachury (J. Cell Sci. 123, 511-518), ‘Flagellar and c...
متن کاملEnteric neurons show a primary cilium
The primary cilium is a non-motile cilium whose structure is 9+0. It is involved in co-ordinating cellular signal transduction pathways, developmental processes and tissue homeostasis. Defects in the structure or function of the primary cilium underlie numerous human diseases, collectively termed ciliopathies. The presence of single cilia in the central nervous system (CNS) is well documented, ...
متن کاملMaxence Nachury: A transporting view of the primary cilium
JCB • VOLUME 191 • NUMBER 3 • 2010 436 R ecent years have seen an explosion of interest in the primary cilium. This long-neglected organelle was widely considered to be an evolutionary dead end before its critical function in cell signaling began to be uncovered. The microtubule-based membrane protrusion is now thought of as a cellular antenna, receiving extracellular signals and transmitting t...
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ژورنال
عنوان ژورنال: Organogenesis
سال: 2013
ISSN: 1547-6278,1555-8592
DOI: 10.4161/org.25144